Joshua Hale

My research focuses on the development of high-precision biophysical tools to better understand the complex molecular mechanisms of heart failure, specifically the role of cardiac myosin binding protein-C. For this work, I utilize novel optical systems and surgical techniques to measure in-vivo cardiac calcium-pressure coupling in mice. Additionally, I seek to improve the clinical management of heart failure patients, for which I develop non-invasive devices to monitor cardiac output in an outpatient or home setting.