Our research program is dedicated to understanding how sarcomeric proteins regulate skeletal and cardiac muscle development, structure, function, and aging in health and disease. We focus on the Myosin Binding Protein-C (MyBP-C) family, including slow skeletal (sMyBP-C; MYBPC1), fast skeletal (fMyBP-C; MYBPC2), and cardiac (cMyBP-C; MYBPC3), to define their roles in sarcomere assembly, thick filament regulation, contractile function, and muscle regeneration. Using genetically engineered mouse models, human iPSC-derived muscle systems, in-depth muscle mechanics, SRX/DRX analysis, X-ray diffraction, advanced imaging, and multi-omics approaches, we investigate the molecular mechanisms underlying inherited muscle diseases, including MYBPC1-associated distal arthrogryposis, congenital myopathies, and MYBPC3-associated hypertrophic cardiomyopathy (HCM). Our long-term goal is to translate these mechanistic discoveries into novel therapies by developing and evaluating small molecules, adeno-associated virus (AAV)-based gene therapies, and antisense oligonucleotides (ASOs) to improve outcomes for patients with genetic cardiac and skeletal muscle diseases.